Three licensed platforms:
- Intranasal (e.g., Nobivac® Intra-Trac): rapid mucosal immunity within 48–72 h.
- Oral (Bronchi-Shield® Oral): similar onset, easy to administer.
- Injectable (Recombitek® C4): systemic immunity; onset 7–10 days.
Intranasal and oral products stimulate IgA at the respiratory epithelium and are preferred for boarding, daycare, and show dogs.