What antibiotics treat pertussis in humans?

Comprehensive answer, prevention tips, related terms, and key take-aways.

Azithromycin 500 mg on day 1, then 250 mg daily for 4 days (preferred)
Clarithromycin 500 mg BID for 7 days
TMP-SMX if macrolide-intolerant (14 days)

Antibiotics shorten contagiousness but have limited impact on cough duration if started after paroxysmal phase.

Key Take-Aways

  • Macrolides are first-line.
  • Start early to reduce spread.
  • Cough may persist despite therapy.